The Science of Glycobiology and 100% Plant-Based Vitamins/Minerals.

For Science Validation of Products
Author Affilations
*Corresponding author:
1: Nutritional Physiology Research Centre, Sansom Institute for Health Research, University of South Australia, Adelaide, Australia
2: Centre for Human Psychopharmacology, Swinburne University of Technology, Melbourne, Australia
3: Clinical Nutrition Research Centre, University of Newcastle, Newcastle, Australia
4: School of Psychology, Social Work and Policy, University of South Australia, Adelaide, Australia
    Glyconutritionals and Real Food Technology Supplementation
are important for your body to function optimally at the cellular level.

Transforming Glycoscience: A Roadmap for the Future
Report from National Academy of Science
Glycoscience-Report-Brief-Final-1 copy.pdf Glycoscience-Report-Brief-Final-1 copy.pdf
Size : 438.37 Kb
Type : pdf
Acetylated Mannan
You can't get top grade
from other companies.

            Click Aloe------->
"Striking differences in Aloe Vera gel carbohydrate composition, molecular weight and particle size distributions following processing will not be addressed by dietary supplement GMPs"

Manapol powder is extracted from fresh, washed and filtered aloe vera gel by a specialized extraction method that yields insoluble fibers and stabilized, high molecular weight (MW) soluble fibers rich in long-chain mannose sugars—β-(1-4)-acetylated polymannans. The MW of over 20% of Manapol is >800,000. It also contains the monosaccharide sugars arabinose, fucose, galactose, galacturonic acid, glucosamine, glucose, glucuronic acid, rhamnose and xylose (1),(2),(3). Ambrotose complex powder provides an excellent source of Manapol powder.
What are they and What do they do?

Meet Dr. Bill McAnalley!

Back in the 1980s, scientists were accustomed to attributing the benefits of foods and medicinal plants to their constituent vitamins, minerals, fats or proteins. Back then, Dr. Bill McAnalley (who later became Mannatech’s first Chief Science Officer) and other scientists discovered that many of the amazing topical and oral benefits of aloe vera gel could be attributed to a polysaccharide (that Dr. McAnalley isolated in its stabilized [acetylated] form and named Acemannan). Researchers demonstrated that these mannose-rich long chains of sugars in aloe vera gel provided impressive immune system support.* Dr. McAnalley then developed the Manapol extract by modifying Acemannan so that it was suitable for human dietary intake.

Dr. McAnalley soon became interested in the role that mannose plays in human cellular communication, and went on to develop Mannatech’s second and third generation glyconutritional dietary supplements, Ambrotose® complex and Advanced Ambrotose® products. Leading the way as a pioneer in glyconutritional technology, Mannatech remains committed to the science of life-changing wellness possibilities. To date, more than 50 patents related to the technology behind our Ambrotose products have been issued globally, and these products are available exclusively through Mannatech.


History of Glyconutrient Research

The discovery of the 8 essential glyconutrients dates back to the 1980s when Dr Bill McAnalley, a research pharmacologist commenced investigations to determine the active ingredient in Aloe Vera. Several years later he discovered the active ingredient was a carbohydrate with many mannose sugar molecules linked together. But it wasn't as simple as just extracting the mannose from the aloe, the mannose needed to be stabilised as it became inactive quite quickly. A method was developed to stabilise mannose and now over 100 patents protect this process in numerous countries.

The research findings commenced to appear in scientific journals such as Glycobiology Journal and Journal of Biotechnology. In 1990 the Journal of Biotechnology states: 'Almost without exception, whenever two or more living cells interact in a specific way, cell surface carbohydrates will be involved.'

This period was followed by several years of science validation which led eventually to the knowledge of the importance of the 8 essential glyconutrients being mainstreamed. Mannatech became a leader in scientific research and development in 1994, and continues to leads the industry.

Synthetics are not Optimal

for your health!

Unfortunately, that's what everyone is supplementing with.  

Real Food Technology Supplements are the ONLY

kind that will get into the cells, 

Not the just the gut!

Click on picture tiles below. 

Facts you should know about Vitamins & Minerals

The difference is clear!
You don't even have to understand science to see what looks more natural.

by Judith A. DeCava, MS, LNC

Click to enlarge pictures of Natural vs Synthetics

For Better, Mind Body and Spirit, Glyconutritionals and Real Food Technology Supplementation are Essential!

Our investment of over $50 million in research and product development has paid dividends in bringing real technology to the wellness world.

We pride ourselves on having one of the most advanced in-house research and development labs in the industry. Our scientists have pioneered many advancements in the wellness industry, including the groundbreaking discovery of glyconutrients and the development of Real Food Technology® solutions—our method of using plant-based, naturally occurring ingredients to create nutritional supplements.

Our Science Team is unmatched and has filed more than 50 patents worldwide for the technology behind our Ambrotose® products, guaranteeing you some of the most unique products available in the market. We strongly believe in and vigorously defend our product patents against infringement by other companies.

From research and development to clinical trials, we hold ourselves to the most stringent standards and are so well respected in the industry, we even help train PhD candidates from the University of Texas. Mannatech research is often published in peer-reviewed scientific journals, and we also rely on third-party validation to create the most results-based products possible.

You will not find a more experienced and committed team of scientists and researchers strategically aligned to identify and develop high-quality, innovative, proprietary products designed to meet your wellness needs.